Volume 44 - Issue 4 - 549 - 558

Synthesis, Structural Characterization, and Water Solubility of a Novel Modified Poly(maleic anhydride-co-vinyl acetate)/Acriflavine Conjugate

Yeni Modifiye Poli(maleik anhidrid-ko-vinil asetat)/Akriflavin Konjugatının Sentezi, Yapısal Karakterizasyonu ve Suda Çözünürlüğü

Novel functional poly(maleic anhydride-co-vinyl acetate)/acriflavine conjugate, MAVA/AF, was synthesized in two different ways that copolymer:drug ratio was designed as 1:1 and 1:2, respectively. Nontoxic poly- meric drug carrier was prepared for conjugation reaction. The purified copolymer, MAVA, was modified with an antiexternal fungal and anticancer active agent acriflavine (AF) at 60°C for 72 hours in dimethylformami- de (DMF), using triethylamine (TEA) as the catalyst. Structural characterizations were carried out by Fourier Transform Infrared (FTIR) and Nuclear Magnetic Resonance (1H-NMR). The spectroscopic results confirmed that conjugated/modification reaction was successfully carried out by amidification reaction. 

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