Volume 44 - Issue 4 - 535 - 548

Electrochemical Detection of Antioxidant Activities of 1,4-Dihydropyridine Derivatives

1,4-Dihidropiridin Türevlerinin Antioksidan Aktivitelerinin Elektrokimyasal Tayini

Antioxidant is a molecule which retards the autooxidation of fats and oils. Antioxidants block the oxidation process which can cause damage to many cells in body helping to prevent diseases. Therefore, the importance of antioxidant is in increasing demand. So far many attempts have been carried out for developing to detect antioxidant activities. Among various analytical techniques, electrochemistry has been a more approp- riate way to determine antioxidant activity due to its ease of use and short-lasting application. In this study, it was aimed to determine antioxidant activities of recently synthesized condensed 1,4-dihydropyridine derivatives using disposable pencil graphite electrode. Cyclic voltammetry technique was used to determine oxidation potential value, and also differential pulse voltammetry technique was used to determine reduction potential values of the derivatives. To verify our results, nifedipine was used as a reference drug and conventional antioxidant activities were also used as a basis for comparison. 

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