Volume 43 - Issue 3 - 187 - 193

Investigation of The Effects of Some Edible Mushroom Extracts on Human Carbonic Anhydrase Isozymes

Bazı Yenebilir Mantar Ekstrelerinin İnsan Karbonik Anhidraz İzozimleri Üzerine Etkilerinin İncelenmesi

In this study the effects of four edible mushroom species (Lentinula edodes, Lactarius deliciosus, Lactarius deterrimus, Terfezia boudieri) on human carbonic anhydrase isozymes (hCA I and hCA II) were investiga- ted as in vitro. hCA I and II isozymes were purified from erythrocytes by using Sepharose®4B-L-tyrosine-p- aminobenzene sulfonamide affinity chromatography. Later the effects of the mushroom extracts on the hydra- tase and esterase activities of hCA I and II were measured. L. edodes showed inhibitory effect on the esterase activities of hCA I and II. However, other extracts showed activator effects on the esterase activities of hCA I and II. 

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