Volume 40 - Issue 2 - 183 - 194

Bioengineering Functional Copolymers. XX. Synthesis of Novel Anticancer Active Poly(maleic anhydride-alt-2-vinyl-1,3-dioxolane) and its Organoboron Amide-Ester Branched Derivatives ​

Biyomühendislik Fonksiyonel Kopolimerleri. XX. Yeni Antikanser Aktif Poli(maleik anhidrid-alt-2- vinil-1,3-dioxolan) ve Organoboron Amid-Ester Dallanmış Türevleri


Novel bioengineering alternating copolymer and its organoboron amide and a-hydroxy-w- methoxypoly(ethylene oxide) (PEO) branched derivatives were synthesized by (1) complex-radical alternating copolymerization of two non-homopolymerizable in chosen reaction conditions monomers such as maleic anhydride (MA) and 2-vinyl-1,3-dioxolane (VDO), (2) amidolysis of synthesized poly(MA-alt-VDO) with 2-aminoethyldiphenylboronate and (3) esterification-grafting of organoboron copolymer with PEO. The complex-formation (Kc) and the monomer reactivity ratios (r1 and r2 copolymerization constants), structure and composition of the synthesized copolymers were characterized by chemical (alkali titration), FTIR-ATR and NMR spectroscopy, TGA-DSC thermal analysis methods. Cytotoxicity found as having an order as organoboron branched PEO copolymer < poly(MA-alt-VDO) < organoboron copolymer of these novel copolymers containing a combination of ionizable, hydrophilic/hydrophobic, organoboron, carboxyl-amide-ester-ether groups, toward HeLa cells was investigated. 



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