Volume 45 - Issue 2 - 163 - 174

Classical and Microwave-Assisted Synthesis of Substituted- Dihydroxy-imidazolidine-2-thiones Compounds

Sübstütiye Dihidroksi-imidazolidin-2-tiyon Bileşiklerinin Klasik ve Mikrodalga Destekli Sentezi


In this study, N-N’-disubstitued thiourea and N-N’-disubstituted-4,5-dihydroxy-2-imidazolidine-2-thione were prepared through the reaction of suitable primary aromatic amines with phenylisothiocyanate and 4-met- hoxyphenylisothiocyanate. The synthesis of N-N’-disubstitued thiourea were carried out by classic methods. Later, the acid-catalyzed cyclocondensation in refluxing acetonitrile of aqueous glyoxal and led to the formati- on of the corresponding N,N’-disubstitued-4,5-dihydroxyimidazolidin-2-thiones. Thiourea derivatives were pre- pared both classical method and microwave assisted synthesis. Microwave-assisted reaction was performed in temperature and pressure control devices with the atmospheric pressure environment. The structures of synthesized organic compounds were characterized by FT-IR and 1HNMR spectroscopy. 



Download Article in PDF (377 kB)



Feedback
  • ISSN 1303 5002
  • © 1973-2019 Hacettepe University