Volume 42 - Issue 1 - 63 - 69

Preparation of collagen based composite materials with synthetic polymers for potential wound dressing applications

Potansiyel yara örtü uygulamaları için kollajen esaslı kompozit malzemelerin sentetik polimeler ile hazıranması

Collagen is very important part of the fibrous proteins in the living organism. Animal tissues, especially tendons main structure contain collagen. In this investigation, natural collagen (coll) modified with differ- ent synthetic monomers such as 2-hydroxy ethylmethacrylate (HEMA) and acrylamide (AAm) was prepared as p(Coll-co-HEMA) and p(Coll-co-AAm) composites to enhance collagen natural characteristics. Biocompatibility of the prepared interpenetrating polymeric network (IPN) was tested with MTT Assay and found biocompat- ible. Model drugs, such as Trimetoprim (TMP) and Naproxene (NP) were used as antibacterial active agents for release studies from the synthesized composite hydrogel-collagen IPN matrices. The drug-loaded IPN films release studies were carried out in bio-mimetic media. It was found that collagen-synthetic polymer matrices can be readily prepared and used for drug delivery system in the release of active agents, providing great po- tential in wound dressing applications. 

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