Volume 41 - Issue 3 - 289 - 299

Poly(amidoamine) (PAMAM) Nanoparticles: Synthesis and Biomedical Applications

Poli(amidoamin) (Pamam) Nanopartiküller: Sentezi ve Biyomedikal Uygulamaları

PAMAM dendrimers are a novel class of spherical, well-designed branching polymers with interior cavities and abundant terminal groups on the surface which can form stable complexes with drugs, plasmid DNA, oligonucleotides and antibodies. Biodegradability, non-toxicity, non-immunogenicity and multifunctionality of PAMAM dendrimer are the key factors which facilitate steady increase of its application in drug delivery, gene transfection, tumor therapy, and diagnostics applications with precision and selectivity. This review deals with the major topics of PAMAM dendrimers including structure, synthesis, toxicity, surface modification, and also possible new applications of these spherical polymers. 

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