Extracorporeal therapies are directed at the removal of potential toxic substances including bilirubin, pathogenic antibodies, various circulating immune-complexes, cholesterol, toxic metal ions, etc. from human plasma. The conventional extracorporeal therapies including plasma exchange, hemodialysis, hemofiltration and hemoperfusion are non-selective techniques. In addition the requirement for plasma substitutes such as albumin is very high. Moreover, the dangers of hepatitis or immune reactions accompany these therapies while using plasma for plasma products. Today, one of the most promising procedures for extracorporeal therapy is specific affinity adsorption. Affinity carriers may be used in hemoperfusion system, where blood is directly perfused through the column filled with these carriers. This type of application is effective, simple and inexpensive. In this article, some interesting applications on extracorporeal affinity therapies for removal of toxic substances from human plasma are briefly reviewed.