Volume 45 - Issue 3 - 403 - 409

The Influence of The Biopsy Procedure on The Quality of a Three-Dimensional Reconstructed Artificial Tissue

Biyopsi Yönteminin Geliştirilen Üç Boyutlu Yapay Dokunun Kalitesine Olan Etkisi

The aim of the present study was to investigate the impact of the initial biopsy harvest procedure on the quality of the final reconstructed tissue. For this purpose, two full-thickness human oral mucosa models were reconstructed by tissue engineering from epithelial cells and fibroblasts obtained via punch or laser biopsy procedures and they were analyzed by using histology, immunohistochemistry, and transmission electron microscopy. The results showed that the oral mucosa model reconstructed by using punch biopsy mimicked very closely the native oral mucosa both morphologically and histologically; on the other hand, laser biopsy resulted in an artificial oral mucosa with less desirable properties.

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