Volume 45 - Issue 2 - 257 - 261

Inhibiting Downstream Signaling Pathway of FIT3 in Acute Myeloid Leukemia

Akut Myeloid Lösemide FLT3 Sinyalizasyon Yolakının Akış Yönünde İnhibisyonu

FLT3 is a type 3 tyrosine kinase receptor susceptible to different genetic mutations in acute myeloid leukemia. Several studies have shown that a large number of patients (approximately one third) have mutations of this gene, lead of which is internal tandem duplications (ITD) that leads to activation of downstream signa- ling pathway and abnormal cellular growth. We used specific target inhibitors to elucidate the combined effects of NOX4 inhibition and the inhibition of FLT3-ITD tyrosine kinase on FLT3-ITD signal transduction. 

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