Volume 44 - Issue 3 - 293 - 305

Synthesis, Antioxidant, Xanthine Oxidase and Urease Inhibitory Activities of Some Chlorine Containing Benzimidazoles

Bazı Klor İçeren Benzimidazollerin Sentezi ve Antioksidan, Ksantin Oksidaz ve Üreaz İnhibitör Aktivitelerinin İncelenmesi


Aseries of tetra-substitued benzimidazole derivatives were synthesized and screened for their urease inhibi- tion, anti-xanthine oxidase (XO) and antioxidant activities. Some of them were found to possess significant antioxidant activity, especially, compounds 4, 5a, 5b, 5c, 5d and 6b exhibited highly scavenging activity in ABTS•+ radical cation decolorization assay (SC50: 9.51-70.43 μg/mL) and cupric reducing antioxidant capacity (CUPRAC) assay. Compound 6d exhibited the highest XO inhibition at 125 μg/mL. All compounds were evalua- ted with regard to Jack Bean urease activity and the most active compound concerning urease enzyme inhibi- tion was (5b), with an IC50 value of 7.41±0.13 μg/mL. 



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