Volume 43 - Issue 3 - 145 - 152

Simultaneous Determination of Irbesartan and Hydrochlorothiazide in Tablets by CE-DAD

İrbesartan ve Hidroklorotiyazidin CE-DAD ile Tabletlerden Eşzamanlı Miktar Tayin

Acapillary electrophoretic method was developed and validated for the simultaneous determination of irbesartan and hydrochlorothiazide in tablets. The run buffer was used 10 mM borate buffer containing 10% methanol (pH 9.0). Compounds were separated less than 6 minutes. The limit of quantification (LOQ) values were 3.370×10-7 M (0.144 μg/mL) and 3.140×10-7 M (0.094 μg/mL) for irbesartan and hydrochlorothiazide, respectively. The method was applied successfully to both irbesartan and irbesartan/hydrochlorothiazide combi- ned tablets with good recoveries almost 100%. 

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