Volume 43 - Issue 2 - 127 - 132

Efficient and Green Synthesis of Mono- and Disubstituted 2,3-Dihydroquinazolin-4(1H)-Ones Using Squaric Acid as a New Organocatalyst in Water

Yeni Sulu Organokatalizör Skuarik Asit Varlığında Mono ve Disübstitüye 2,3-Dihidroksikuinazolin- 4(1H)-Ones’un Etkin ve Yeşil Sentezi


Asimple and facile synthesis of mono- and disubstituted 2,3-dihydroquinazolin-4(1H)-one derivatives has been successfully developed by treatment of aldehydes, ammonium acetate, and isatoic anhydride under reflux conditions in the presence of a squaric acid organocatalyst. These catalytic condensation reactions represent green chemical processes and the squaric acid organocatalyst is air-stable, cost-effective, easy to handle, and easily removed from the reaction. 



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