Optimization of medium conditions for Cd(II) adsorption by pumice was studied through experimental designs. A multi step response surface methodology (RSM) including 26-2 fractional factorial design (FFD), steepest ascent and central composite design (CCD) was successfully applied to optimize the adsorption conditions for Cd(II) ions from aqueous solutions. The most influential medium parameters were determined as pH, initial Cd(II) concentration and temperature via FFD. Then steepest ascent was used to determine the neighborhood region of the optimum point. Finally, CCD was applied to develop a response surface for optimization of adsorption conditions. The optimum conditions for Cd(II) adsorption were evaluated to be 7.01, 107.14 mg/L and 32.48°C for pH, initial Cd(II) concentration and temperature, respectively. A quadratic model was developed by CCD to represent Cd(II) ions adsorption.