Volume 40 - Issue 4 - 401 - 407

A Validated RP-HPLC Method for the Estimation of Ornidazole in Pharmaceutical Dosage Forms

Ornidazol’ün Farmasötik Dozaj Formlarından Valide Edilmiş RP-HPLC Metodu ile Belirlenmesi


Anew, simple, rapid, selective, precise and accurate isocratic reverse phase high performance liquid chromatography assay has been developed and validated for assay of Ornidazole in tablet formulations. Tinidazole was used as an internal standard. These compounds are separated well on a X-Terra (Waters Corp., Milford, MA, USA) RP-18 column by using a mobile phase consisting of a mixture of acetonitrile : water (30:70; v/v) adjusted to pH 3.00 with 10 mM o-phosphoric acid at a flow rate of 1.0 mL min-1. The method was validated as per the ICH guidelines. 



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