Volume 39 - Issue 2 - 157 - 162

Glucose 6-Phosphate Dehydrogenase Activatory Properties of Some Organic Compounds and Amino Acids

Bazı Organik Bileşikler ve Amino Asitlerin Glukoz 6-Fosfat Dehidrogenaz Aktivatör Özellikleri

The aim of this study was to assess activatory potentials of 4’-(Methylsulfonyl)- acetophenone, 4-(methylsul- fonyl) phenylacetic acid, tyrosine and phenylalanine on human erythrocyte glucose 6-phosphate dehydro- genase. For this purpose, initially erythrocyte glucose 6-phosphate dehydrogenase was managed to be purified 812-fold in a yield of 40.6% by using 2’,5’-ADP Sepharose 4B affinity gel.

4’-(Methylsulfonyl)acetophenone, 4-(methylsulfonyl)phenylacetic acid, tyrosine and phenylalanine exhib- ited activatory effects on the enzyme. % Activity values for these compounds were determined by plotting activity percentage versus [Activator]. 

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